Respiratory Combination Products
A to Z Drug Facts
Respiratory Combination Products
Upper Respiratory Combinations
Antibiotic Combinations
Gastrointestinal Anticholinergic Combinations
Narcotic Analgesic Combinations
Nonnarcotic Analgesic Combinations
Diuretic Combinations
Migraine Combinations
| Respiratory Combination Products |
These combination products are presented in groups based on the components of their formulations.
Antiasthmatic Combinations
Antiasthmatic combinations contain xanthine derivatives and sympathomimetics for bronchodilation. Many products also contain expectorants to facilitate mobilization of mucus.
Upper Respiratory Combinations
Upper respiratory combinationsare used primarily for relief of symptoms associated with colds, upper respiratory infections, and allergic conditions (eg, acute rhinitis, sinusitis).
Ingredients
Antihistamines: Antihistamines are used for symptomatic relief from allergic rhinitis (hay fever) including runny nose, sneezing, itching of the nose or throat, and itchy and watery eyes. The anticholinergic effects of antihistamines may cause a thickening of bronchial secretions; therefore, these agents may be counterproductive in respiratory conditions characterized by congestion. Antihistamines may cause drowsiness.
Xanthines: Xanthines, primarily theophylline, relieve bronchial spasm by direct action on the bronchial smooth muscle in bronchospastic conditions such as asthma and chronic bronchitis. Some xanthine-containing combination products are available over-the-counter, but asthmatic patients should use them only under physician supervision.
Sympathomimetics: Sympathomimetics are used for their vasoconstrictor/decongestant or bronchodilator effects.
Decongestants: Decongestants are used for temporary relief of nasal congestion due to colds or allergy. Given orally, they are less effective than topical nasal decongestants and have a potential for systemic side effects. Frequent or prolonged topical use may lead to local irritation and rebound congestion.
Bronchodilators: Ephedrine is common in these combinations; however, it stimulates cardiac (b1) receptors. Bronchodilation is weaker than with the catecholamines: a-adrenergic effects may decrease congestion of mucous membranes. Other b-active agents are effective bronchodilators, but pseudoephedrine is not.
Analgesics: Analgesics (eg, acetaminophen, aspirin, ibuprofen, sodium salicylate) are frequently included for symptoms of headache, fever, muscle aches, and pain.
Anticholinergics: Anticholinergics are included for their drying effects on mucous secretions. This action may be beneficial in acute rhinorrhea; however, drying of respiratory secretions may lead to obstruction. Traditionally, anticholinergics have been avoided in patients with asthma or chronic obstructive pulmonary disease (COPD); however, some patients respond well to these agents. Caution is still advised in this group.
An anticholinergic for oral inhalation is available as a bronchodilator for maintenance of bronchospasm associated with COPD, including chronic bronchitis and emphysema.
Papaverine HCl: Papaverine HCl relaxes the smooth muscle of the bronchial tree.
Barbiturates: Barbiturates are included for their sedative effects as “correctives” in combination with xanthines or sympathomimetics, which may cause CNS stimulation. The sedative efficacy of low doses (eg, 8 mg phenobarbital) is questionable.
Caffeine: Caffeine is included in some combinations for CNS stimulation to counteract antihistamine depression and to enhance concomitant analgesics.
| Antiasthmatic Combinations | ||
| Trade Name | Strength/Ingredient | Average Dose |
| Quibron-300 Capsules | 300 mg theophylline, 180 mg guaifenesin | 16/mg/kg/day or 400 mg/day in divided doses, q 6 to 8 h |
| Bronchial Capsules, Quibron Capsules | 150 mg theophylline, 90 mg guaifenesin | 16/mg/kg/day or 400 mg/day in divided doses, q 6 to 8 h |
| Glyceryl-T Capsules | 150 mg theophylline, 90 mg guaifenesin | 1 or 2 bid or tid |
| Slo-Phyllin GG Capsules1,2 | 150 mg theophylline, 90 mg guaifenesin | 3 mg/kg/day q 6 to 8 h |
| Mudrane GG-2-Tablets | 111 mg theophylline, (130 mg aminophylline anhydrous), 100 mg guaifenesin | 1 tid or qid |
| Dilor-G Tablets | 200 mg dyphylline, 200 mg guaifenesin | 1 tid or qid |
| Dyflex-G Tablets | 200 mg dyphylline, 200 mg guaifenesin | 1 or 2 qid |
| Dyline G.G. Tablets | 200 mg dyphylline, 200 mg guaifenesin | 1 tid or qid |
| Lufyllin-GG Tablets | 200 mg dyphylline, 200 mg guaifenesin | 1 qid |
| Glyceryl-T Liquid, Theolate Liquid | 150 mg theophylline, 90 mg guaifenesin per 15 ml | 15 ml q 6 to 8 h |
| Slo-Phyllin GG Syrup1,3,4 | 150 mg theophylline, 90 mg guaifenesin per 15 ml | 3 mg/kg/day q 6 to 8 h |
| Synophylate-GG Syrup1,3,4 | 150 mg theophylline, (300 mg theophylline sodium glycinate), 100 mg guaifenesin, 10% alcohol per 15 ml | 3 mg/kg q 8 h |
| Elixophyllin GG Liquid1 | 100 mg theophylline, 100 mg guaifenesin per 15 ml | 3 mg/kg q 8 h |
| Theophylline Kl Elixer | 80 mg theophylline, 130 mg potassium iodide per 15 ml, | 3 mg/kg q 8 h |
| Trade Name | Strength/Ingredient | Average Dose |
| Elixophyllin-Kl Elixir3,4 | 80 mg theophylline, 130 mg potassium iodide, per 15 ml, 10% alcohol, sodium bisulfite, anise oil | 3 mg/kg q 8 h |
| Iophylline Elixir | 120 mg theophylline, 30 mg iodinated glycerol per 15 ml | 15 to 30 ml tid |
| Dilor-G Liquid,1,3,4 Dyline-GG Liquid1,3,4 |
300 mg dyphylline, 300 mg guaifenesin per 15 ml | 5 or 10 ml tid or qid |
| Lufyllin-GG Elixir3,4 | 100 mg dyphylline, 100 mg guaifenesin per 15 ml, 17% alcohol | 30 ml qid |
| Brondelate Elixir | 192 mg theophylline (300 mg oxtriphylline), 150 mg guaifenesin per 15 ml, alcohol | 10 ml qid |
| Hydrophed Tablets, Marax Tablets | 130 mg theophylline, 25 mg ephedrine sulfate, 10 mg hydroxyzine HCl | 1 bid to qid |
| Mudrane GG Tablets | 111 mg theophylline (130 mg aminophylline anhydrous), 16 mg ephedrine HCl, 100 mg guaifenesin, 8 mg phenobarbital | 1 tid or qid |
| Mudrane Tablets | 111 mg theophylline (130 mg aminophylline anhydrous), 16 mg ephedrine HCl, 195 guaifenesin, 8 mg phenobarbital | 1 tid or qid |
| Quadrinal Tablets | 65 mg theophylline (130 mg theophylline calcium salicylate), 24 mg ephedrine HCl, 320 mg potassium iodide, 24 mg phenobarbital | 1 tid or qid |
| Lufylline-EPG Tablets5 | 100 mg dyphylline, 16 mg ephedrine HCl, 200 mg guaifenesin, 16 mg phenobarbital | 1 to 2 q 6 h |
| Lufylline-EPG Elixir3,4 | 150 mg dyphylline, 24 mg ephedrine HCl, 300 mg guaifenesin, 24 mg phenobarbital per 15 ml, 5.5% alcohol, methylparaben | 10 to 20 ml q 6 h |
| Theomax DF Syrup | 97.5 mg theophylline, 18.75 ephedrine, 7.5 mg hydroxyzine HCl per 15 ml, alcohol | Children (> 5 yrs): 5 ml tid or qid; (2 to 5 yrs) 2.5 to 5 ml tid or qid |
| Upper Respiratory Combinations |
| Upper Respiratory Combinations | ||
| Trade Name | Strength/Ingredient | Average Dose |
| Cophene No. 2 Capsules, Rescon Capsules | 120 mg pseudoephedrine HCl, 12 mg chlorpheniramine maleate | 1 q 12 h |
| Anamine T.D. Capsules | 120 mg pseudoephedrine HCl, 8 mg chlorpheniramine maleate | 1 q 8 to 12 h |
| Brexin L.A. Capsules, Chlorafed Timecelles, Chlordrine S.R. Capsules, Chlorphedrine SR Capsules, Codimal-L.A. Capsules, Colfed-A Capsules, Deconamine SR Capsules, Deconomed SR Capsules, Duralex Capsules, Fedahist Timecaps Capsules, Klerist-D Capsules, Kronofed-A Capsules, N D Clear Capsules, Novafed A Capsules, Pseudo-Chlor Capsules, Rescon-ED Capsules, Rinade B.I.D. Capsules, Time-Hist Capsules | 120 mg pseudoephedrine HCl, 8 mg chlorpheniramine maleate | 1 q 12 h |
| Fedahist Gyrocaps | 65 mg pseudoephedrine HCl, 10 mg chlorpheniramine maleate | 1 q 12 h |
| Chlorafed H.S. Timecelles, Codimal-L.A. Half Capsules | 60 mg pseudoephedrine HCl, 4 mg chlorpheniramine maleate | 1 or 2 q 12 h |
| Ed A-Hist Tablets, Prehist Capsules | 20 mg phenylephrine HCl, 8 mg chlorpheniramine maleate | 1 q 12 h |
| Allent Capsules, Bromfed Capsules, Endafed Capsules, Iofed Capsules, ULTRAbrom Capsules | 120 mg pseudoephedrine HCl, 12 mg brompheniramine maleate | 1 q 12 h |
| Carbodec Syrup,1 Cardec-s Syrup | 60 mg pseudoephedrine HCl, 4 mg carbinoxamine maleate per ml | 5 ml qid |
| Biohist-LA Tablets, Carbiset-TR Tabs, Carbodec TR Tabs, Rondec-TR Tablets | 120 mg pseudoephedrine HCl, 8 mg carbinoxamine maleate | 1 q 12 h |
| Trinalin Repetabs | 120 mg pseudoephedrine HCl, 1 mg azatadine maleate | 1 bid |
| Bromfenex PD,4 Iofed PD, Lodrane LD Capsules, Respahist Capsules, Touro A & H Capsules | 60 mg pseudoephedrine HCl, 6 mg brompheniramine maleate | 1 or 2 q 12 h |
| Trade Name | Strength/Ingredient | Average Dose |
| Bromfed Tablets | 60 mg pseudoephedrine HCl, 4 mg brompheniramine maleate | 1 q 4 h |
| Deconamine Tablets, Klerist-D Tablets | 60 mg pseudoephedrine HCl, 4 mg chlorpheniramine maleate | 1 tid or qid |
| Semprex-D Capsules | 60 mg pseudoephedrine HCl, 8 mg acrivastine | 1 q 4 to 6 h up to 4/day |
| Hitussin D,* H-Tuss-D8 | 60 mg pseudoephedrine HCl, 5 mg hydrocodone bitartrate per 5 ml | 5 ml qid |
| Bromfenex,4 Iofed | 120 mg pseudoephedrine HCl, 12 mg brompheniramine maleate | 1 q 12 h |
| Disobrom Tablets, Dexaphen-S.A. Tablets, Drixomed | 120 mg pseudoephedrine sulfate, 6 mg dexbrompheniramine maleate | 1 q 12 h |
| Claritin-D Tablets | 120 mg pseudoephedrine sulfate, 5 mg loratadine | 1 q 12 h |
| Claritin-D 24-Hour | 10 mg loratadine, 240 mg pseudoephedrine sulfate | daily |
| Drize Capsules, Ornade Spansules, Resaid Capsules, Rhinolar-EX 12 Capsules | 75 mg phenylpropanolamine HCl, 12 mg chlorpheniramine maleate | 1 q 12 h |
| Dura-Vent/A Capsules | 75 mg phenylpropanolamine HCl, 10 mg chlorpheniramine malete | 1 q 12 h |
| Rhinolar-EX Capsules | 75 mg phenylpropanolamine HCl, 8 mg chlorpheniramine maleate | 1 q 12 h |
| Comhist LA Capsules | 20 mg phenylephrine HCl, 4 mg chlorpheniramine maleate, 50 mg phenyltoloxamine citrate | 1 q 8 to 12 h |
| Nolamine Tablets | 50 mg phenylpropanolamine HCl, 4 mg chlorpheniramine maleate, 24 mg phenindamine tartrate | 1 q 8 to 12 h |
| Poly-Histine-D Capsules | 50 mg phenylpropanolamine HCl, 16 mg phenyltoloxamine citrate, 16 mg pyrilamine maleate, 16 mg pheniramine maleate | 1 q 8 to 12 h |
| Trade Name | Strength/Ingredient | Average Dose |
| Naldecon Tablets, Nalgest Tablets, Uni-Decon Tablets | 40 mg phenylpropanolamine HCl, 10 mg phenylephrine HCl, 5 mg chlorpheniramine maleate, 15 mg phenyltoloxamine citrate | 1 tid |
| Dura-Tap/PD Capsules, Kronofed-A Jr. Capsules, Rescon JR Capsules | 60 mg pseudoephedrine HCl, 4 mg chlorpheniramine maleate | Children (6 to 12 years): 1 q 12 h |
| Atrohist Pediatric Capsules | 60 mg pseudoephedrine HCl, 4 mg chlorpheniramine maleate | Children (6 to 12 years): 1 to 2 q 12 h |
| Bromfed-PD Capsules, Dallergy-JR Capsules, ULTRAbrom PD Capsules | 60 mg pseudoephedrine HCl, 6 mg brompheniramine maleate | Children (6 to 12 years): 1 q 12 h |
| Histine, Iohist DM, Liqui-Histine DM, Poly-Histine DM | 10 mg dextromethorphan HBr, 12.5 phenylpropanolamine HCl, 2 mg brompheniramine maleate per 5 ml | 10 ml q 4 h |
| Poly-Histine D Ped Caps | 25 mg phenylpropanolamine HCl, 8 mg phenyltoloxamine citrate, 8 mg pyrilamine maleate, 8 mg pheniramine maleate | Children (6 to 12 years): 1 q 8 to 12 h |
| Carbiset Tablets, Carbodec Tablets, Rondec Tablets | 60 mg pseudoephedrine HCl, 4 mg carbinoxamine maleate | 1 qid |
| Biohist-LA,5 Carbiset-TR, Carbodec TR, Rondec-TR5,7 | 8 mg carbinoxamine maleate, 120 mg pseudoephedrine HCl | 1 q 12 h |
| Cardec DM, Sildec-DM | 4 mg carbinoxamine maleate, 60 mg pseudoephedrine HCl, 15 mg dextromethorphan HBr per 5 ml | 2.5 to 5 ml qid |
| Comhist Tablets | 10 mg phenylephrine HCl, 2 mg chlorpheniramine maleate, 25 mg phenyltoloxamine citrate | 1 or 2 tid q 8 h |
| Rhinatate Tablets, R-Tannate Tablets, R-Tannamine Tablets, Rynatan Tablets, Tanoral Tablets, Triotann Tablets, Tri-Tannate Tablets | 25 mg phenylephrine tannate, 8 mg chlorpheniramine tannate, 25 mg pyrilamine tannate | 1 or 2 q 12 h |
| Hista-Vadrin Tablets | 40 mg phenylpropanolamine HCl, 5 mg phenylephrine HCl, 6 mg chlorpheniramine maleate | 1 q 6 h |
| Trade Name | Strength/Ingredient | Average Dose |
| ED-TLC Liquid,8 Endagen-HD,8 Para-Hist HD,8 Vanex HD8 | 5 mg phenylephrine HCl, 2 mg chlorpheniramine maleate, 1.67 mg hydrocodone bitartrate per 5 ml | 10 ml tid or qid |
| Endal-HD Plus8, Hitussin HC8 | 5 mg phenylephrine HCl, 2 mg chlorpheniramine maleate, 2.5 mg hydrocodone bitartrate per 5 ml | 10 ml q 4 h up to 40 ml/day |
| Hydrocodone PAPediatric Syrup8 | 12.5 phenylpropanolamine HCl, 2.5 mg hydrocodone bitartrate per 5 ml | 6 to 12 yrs to 5 ml q 4 h |
| Tanafed Suspension | 75 mg pseudoephedrine tannate, 4.5 mg chorpheniramine maleate | 10 to 20 ml q 12 h |
| Brofed Elixir | 30 mg pseudoephedrine HCl, 4 mg brompheniramine maleate per 5 ml | 10 ml tid or qid |
| Ed-A-Hist Liquid | 10 mg phenylephrine HCl, 4 mg chlorpheniramine maleate per 5 ml, 5% alcohol | 5 ml tid or qid |
| AH-Chew, D.A. II, D.A.Chew, Extendryl Chewable Tablets, Extendryl Syrup | 10 mg phenylephrine HCl, 4 mg chlorpheniramine maleate, 1.25 methscopolamine nitrate | 1 q 4 to 6 h |
| Histor-D Syrup | 5 mg phenylephrine HCl, 2 mg chlorpheniramine maleate per 5 ml, 2% alcohol | 5 to 10 ml q 4 to 6 h |
| Prometh VC Plain Liquid | 5 mg phenylephrine HCl, 6.25 mg promethazine per 5 ml, alcohol | 5 ml q 4 to 6 h |
| Phenergan VC Syrup2 | 5 mg phenylephrine HCl, 6.25 mg promethazine per 5 ml, 7% alcohol | 5 ml q 4 to 6 h |
| Carbodec Syrup, Cardec-S Syrup, Rondec Syrup | 60 mg pseudoephedrine HCl, 4 mg carbinoxamine per 5 ml | 5 ml qid |
| Histalet Syrup | 45 mg pseudoephedrine HCl, 3 mg chlorpheniramine maleate per 5 ml | 10 ml qid |
| Anamine Syrup, Anaplex Liquid | 30 mg pseudoephedrine HCl, 2 mg chlorpheniramine maleate per 5 ml | 10 ml q 4 to 6 h |
| Deconamine Syrup | 30 mg d-pseudoephedrine HCl, 2 mg chlorpheniramine maleate per 5 ml | 5 to 10 ml tid or qid |
| Trade Name | Strength/Ingredient | Average Dose |
| Poly-Histine-D Elixir | 12.5 mg phenylpropanolamine HCl, 4 mg pyrilamine maleate, 4 mg phenyltoloxamine citrate, 4 mg pheniramine maleate per 5 ml, 4% alcohol | 10 ml q 4 h |
| Naldecon Syrup | 20 mg phenylpropanolamine HCl, 5 mg phenylephrine HCl, 2.5 mg chlorpheniramine maleate, 7.5 mg phenyltoloxamine citrate | 5 ml q 3 to 4 h up to 20 ml/day |
| Rondec Oral Drops | 25 mg pseudoephedrine HCl, 2 mg carbinoxamine maleate per ml | Infants: 0.25 to 1 ml qid |
| Atrohist Pediatric Suspension, R-Tannamine Pediatric Suspension, R-Tannate Pediatric Suspension,2,3,4 Rynatan Pediatric Suspension,2,3,4 Rynatan-S Pediatric Suspension,2,3,4 Tri-Tannate Pediatric Suspension2,3,4 | 5 mg phenylephrine tannate, 2 mg chlorpheniramine tannate, 12.5 mg pyrilamine tannate per 5 ml | Children (> 6 yrs): 5 to 10 ml q 12 h; (2 to 6 yrs): 2.5 to 5 ml q 12 h |
| Naldecon Pediatric Syrup,1 Tri-Phen-Mine Pediatric Syrup | 1 5 mg phenylpropanolamine HCl, 1.25 mg phenylephrine HCl, 0.5 mg chlorpheniramine maleate, 2 mg phenyltoloxamine citrate per 5 ml | Children (6 to 12 mos): 2.5 ml q 3 to 4 h up to 10 ml/day; (1 to 6 yrs): 5 ml q 3 to 4 h up to 20 ml/day; (6 to 12 yrs): 10 ml q 3 to 4 h up to 40 ml/day |
| Naldecon Pediatric Drops,1 Tri-Phen-Mine Pediatric Drops, | 5 mg phenylpropanolamine HCl, 1.25 mg phenylephrine HCl, 0.5 mg chlorpheniramine maleate, 2 mg phenyltoloxamine citrate per ml | Children (3 to 6 mos): 0.25 ml q 3 to 4 h; (6 to 12 mos): 0.5 ml q 3 to 4 h: (1 to 6 yrs): 1 ml q 3 to 4 h up to 4 doses/day |
| Dallergy Capsules, DuraVent/DA Tablets, Extendryl S.R. Capsules, OMNhist L.A. Tablets, Prehist D Capsules and Tablets | 20 mg phenylephrine HCl, 8 mg chlorpheniramine, 2.5 mg methscopolamine nitrate | 1 q 12 h |
| Trade Name | Strength/Ingredient | Average Dose |
| Atrohist Plus Tablets, Stahist Tablets, | 50 mg phenylpropanolamine HCl, 25 mg phenylephrine HCl, 8 mg chlorpheniramine maleate, 0.19 mg hyoscyamine sulfate, 0.04 mg atropine sulfate, 0.01 mg scopolamine HBr | 1 q 12 h |
| Mescolor Tablets | 120 mg pseudoephedrine HCl, 8 mg chlorpheniramine maleate, 2.5 mg methscopolamine nitrate | 1 q 12 h |
| Deconsal II, Defen-LA, Guaifenex PSE 60, Guiafenex Rx (AM), Guaifenex Rx DM, Iosal II, MED-Rx, MED-Rx DM, Respa-1st, Syn-Rx | 600 mg guaifenesin, 60 mg pseudoephedrine HCl | 1 or 2 q 12 h |
| Duratuss, Entex PSE,7 Fenesin DM, Guaifenex PSE 120, Guaimax-D, Gui-Vent/PSE, Iobid DM, Monafed DM, Muco-Fen-DM, Respa-DM, Ru-Tuss DE, Sudal 120/600, Zephrex LA | 600 mg guaifenesin, 120 mg pseudoephedrine HCl | 1 q 12 h |
| Coldloc-LA, Guaifenex PPA 755, Profen LA, SINUvent | 600 mg guaifenesin, 75 mg phenylpropanolamine HCl | 1 q 12 h |
| Nasatab LA, Touro LA | 500 mg guaifenesin, 120 mg pseudoephedrine | 1 bid |
| Phenylfenesin LA | 400 mg guaifenesin, 75 mg phenylpropanolamine HCl | 1 q 12 h |
| Guaivent PD4 | 300 mg guaifenesin, 60 mg pseudoephedrine HCl | 1 or 2 q 12 h |
| Deconamine CX Tablets | 300 mg guaifenesin, 30 mg pseudoephedrine, 5 mg hydrocodone bitartrate | 1 to 1.5 ml up to qid |
| Guaivent4 | 250 mg guaifenesin, 90 mg pseudoephedrine HCl | 1 q 12 h |
| Norel | 200 mg guaifenesin, 45 mg phenylpropanolamine HCl, 5 mg phenylephrine HCl | 1 qid (q 6 h) |
| Coldloc1, Guaifenex1, Sil-Tex1,2,4,6 | 100 mg guaifenesin, 20 mg phenylpropanolamine HCl, 5 mg phenylephrine HCl per 5 ml | 10 ml q 6 h |
| Trade Name | Strength/Ingredient | Average Dose |
| Guaifenesin and Codeine Phosphate Syrup,6,8 Cheracol Cough Syrup,4,6,8 Guiatuss AC Syrup,6,8 Guiatussin w/Codeine Expectorant Liquid,6,8 Mytussin AC Cough Syrup,6,8 | 100 mg guaifenesin, 10 mg codeine phosphate per 5 ml | 10 ml q 4 h |
| Guiatussin DAC Syrup,2,4,6,8 Isoclor Expectorant Liquid,6,8 Mytussin DAC Liquid,2,4,6,8 Novagest Expectorant w/Codeine Liquid,6,8 Novahistine Expectorant Liquid,2,4,6,7,8 Phenhist Expectorant Liquid,6,8 | 100 mg guaifenesin, 30 mg pseudoephedrine HCl, 10 mg codeine phosphate per 5 ml. 6% alcohol | 10 ml q 4 h up to 40 ml/day |
| Atuss-EX1,2,8 HycoClear Tuss8 Hydrocodone GF Syrup8 | 100 mg guaifenesin, 5 mg hydrocodone bitartrate | 5 ml q 4 h pc and hs |
| Dallergy Tablets | 10 mg phenylephrine HCl, 4 mg chlorpheniramine maleate, 1.25 mg methscopolamine nitrate | 1 q 4 to 6 h |
| AH-chew Tablets, D.A. Chewable Tablets, Extendryl Chewable Tablets | 10 mg phenylephrine HCl, 2 mg chlorpheniramine maleate, 1.25 mg methscopolamine nitrate | 1 or 2 q 4 h |
| Extendryl Syrup | 10 mg phenylephrine HCl, 2 mg chlorpheniramine maleate, 1.25 mg methscopolamine nitrate | 5 or 10 ml q 3 or 4 h qid |
| Dallergy Syrup | 10 mg phenylephrine HCl, 2 mg chlorpheniramine maleate, 0.625 mg methscopolamine nitrate | 10 ml q 4 to 6 h up to 4 doses/day |
| Extendryl JR Capsules | 10 mg phenylephrine HCl, 4 mg chlorpheniramine maleate, 1.25 mg methscopolamine maleate | Children (6 to 12 yrs): 1 q 12 h |
| Antibiotic Combinations |
These antibiotic combinations are used for the treatment of superficial ocular infections involving the conjunctiva or cornea (eg, conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute meibomianitis, dacryocystitis) due to strains of micro-organisms susceptible to antibiotics.
| Combination Antibiotic Products | ||
| Trade Name | Strength/Ingredient | Average Dose |
| AK-Spore Ointment, Neosporin Ophthalmic Ointment, Ocutricin Ointment | 10,000 units/g polymyxin B sulfate, 3.5 mg/g neomycin sulfate, 400 units/g bacitracin zinc | Varies for individual products, refer to manufacturer’s insert |
| AK-Spore Solution, Neosporin Ophthalmic Solution | 10,000 units/ml polymyxin B sulfate, 1.75 mg/ml neomycin sulfate, 0.025 mg/ml gramicidin | Varies for individual products, refer to manufacturer’s insert |
| AK-Poly-Bac Ointment, Polysporin Ophthalmic Ointment | 10,000 units/g polymyxin B sulfate, 500 units/g bacitracin zinc | Varies for individual products, refer to manufacturer’s insert |
| Terak Ointment, Terramycin w/Polymyxin B Ointment | 10,000 units/g polymyxin B sulfate, 5 mg/g oxytetracycline HCl | Varies for individual products, refer to manufacturer’s insert |
| Polytrim Ophthalmic Solution | 10,000 units/ml polymyxin B sulfate, 1 mg/ml trimethoprim | Varies for individual products, refer to manufacturer’s insert |
| Gastrointestinal Anticholinergic Combinations |
GI anticholinergic agents are used primarily to decrease motility (smooth muscle tone) in the GI, biliary, and urinary tracts and for their antisecretory effects.
Combination anticholinergic preparations may include the following components
Barbiturates, prochlorperazine, hydroxyzine, meprobamate, chlordiazepoxide: These components are used as sedatives and antianxiety agents.
Ergotamine tartrate: Ergotamine tartrate provides inhibition of the sympathetic nervous system.
Antihistamines: Antihistamines are used for antihistaminic effects, sedative, or anticholinergic side effects.
Kaolin: Kaolin is used for its adsorbent properties.
| Anticholinergic Combinations | ||
| Trade Name | Strength/Ingredient | Average Dose |
| Barbidonna No. 2 Tablets | 0.025 mg atropine sulfate, 0.0074 mg scopolamine HBr, 0.1286 mg hyoscyamine HBr or SO4, 32 mg phenobarbital | 3 tablets/day |
| Barbidonna Tablets | 0.025 mg atropine sulfate, 0.0074 mg scopolamine HBr, 0.1286 mg hyoscyamine HBr or SO4, 16 mg phenobarbital | 3 to 6 tablets/day |
| Donnatal Capsules and Tablets, Hyosophen Tablets, Spasmolin Tablets | 0.0194 mg atropine sulfate, 0.0065 mg scopolamine HBr, 0.1037 mg hyoscyamine HBr or SO4, 16.2 mg phenobarbital | 3 to 8 capsules or tablets/day |
| Butibel Tablets | 15 mg belladonna extract, 15 mg butabarbital sodium | 4 to 8 tablets/day |
| Chardonna-2 Tablets | 15 mg belladonna extract, 15 mg phenobarbital | 3 to 8 tablets/day |
| Belladenal Tablets | 0.25 mg l-alkaloids of belladonna, 50 mg phenobarbital | 2 to 4 tablets/day |
| Bellacane, Levsin w/Phenobarbital Tablets | 0.125 mg l-hyoscyamine sulfate, 15 mg phenobarbital | 3 to 8 tablets/day |
| Clindex Capsules, Librax Capsules | 2.5 mg clidinium, 5 mg chlordiazepoxide HCl | 3 to 8 capsules/day |
| Donnatal Extentabs | 0.0582 mg atropine sulfate, 0.0195 mg scopolamine HBr, 0.3111 mg hyoscyamine sulfate, 48.6 mg phenobarbital | 2 to 3 tablets/day |
| Bellacane SR Tablets, Bellergal-S Tablets, Bel-Phen-Ergot SR Tablets, Phenerbel-S Tablets | 0.2 mg l-alkaloids of belladonna, 40 mg phenobarbital, 0.6 mg ergotamine tartrate | 2 to 3 tablets/day |
| Bellacane Elixir, Donnatal Elixir1, Hyosophen Elixir, Susano Elixir2 | 0.0194 mg atropine sulfate, 0.0065 mg scopolamine HBr, 0.1037 mg hyoscyamine HBr or SO4, 16.2 mg phenobarbital per 5 ml, 23% alcohol | 15 to 40 ml/day |
| Butibel Elixir | 15 mg belladonna extract, 15 mg butabarbital sodium per 5 ml, 7% alcohol, saccharin | 20 to 40 ml/day |
| Antrocol Elixir | 0.195 mg atropine sulfate, 16 mg phenobarbital per 5 ml, 20% alcohol | Children: 0.5 ml per 15 lbs every 4 to 6 hours |
| Levsin-PB Drops | 0.125 mg hyoscyamine sulfate, 15 mg phenobarbital per ml, 5% alcohol | 1 to 2 ml/day Children: 0.5 to 1 ml/day |
| Narcotic Analgesic Combinations |
Components of these combinations include
Narcotic analgesics: Codeine, hydrocodone bitartrate, dihydrocodeine bitartrate, opium, oxycodone HCl, oxycodone terephthalate, meperidine HCl, propoxyphene HCl, propoxyphene napsylate.
Nonnarcotic analgesics: Acetaminophen, salicylates, salicylamide. Caffeine, a traditional component of many analgesic formulations, may be beneficial to certain vascular headaches.
Magnesium-aluminum hydroxides and calcium carbonate: Magnesium-aluminum hydroxides and calcium carbonate are used as buffers.
Barbiturates, acetylcarbromal, carbromal, and bromisovalum: Barbiturates, acetylcarbromal, carbromal, and bromisovalum are used for their sedative effects.
Promethazine HCl: Promethazine HCl (a phenothiazine derivative with antihistamine properties) is used for its sedative effect.
Belladonna alkaloids: Belladonna alkaloids are used as an antispasmodic.
| Narcotic Analgesic Combinations | ||
| Trade Name | Strength/Ingredient | Average Dose |
| Alor 5–500 Tablets, Azdone Tablets, Damason-P Tablets, Lortab ASA Tablets, Panasal 5/500 Tablets | 5 mg hydrocodone bitartrate, 500 mg aspirin | 1 or 2 q 4 to 6 h up to 8/day |
| Lortab Elixer | 2.5 hydrocodone bitartrate, 167 mg acetaminophen per 5ml. 7% alcohol, saccharin, sorbitol, sucrose, parabens | 15 ml q 4 to 6 h |
| Synalgos-DC Capsules | 16 mg dihydrocodeine bitartrate, 356.4 mg aspirin, 30 mg caffeine | 2 q 4 h |
| Percodan-Demi Tablets | 2.25 mg oxycodone HCl and 0.19 mg oxycodone terephthalate, 325 mg aspirin | 1 or 2 q 6 h |
| Percodan Tablets, Roxiprin Tablets | 4.5 mg oxycodone HCl and 0.38 mg oxycodone terephthalate, 325 mg aspirin | 1 q 6 h |
| Mepergan Injection | 25 mg meperidine HCl, 25 mg promethazine HCl | 1 to 2 ml q 3 to 4 h |
| Mepergan Fortis Capsules | 50 mg meperidine HCl, 25 mg meperidine HCl | 1 q 4 to 6 h |
| Wygesic Tablets | 65 mg propoxyphene HCl, 650 mg acetaminophen | 1 q 4 h |
| Darvon Compound-65 Pulvules | 65 mg propoxyphene, 389 mg aspirin, 32.4 mg caffeine | 1 q 4 h |
| B & O Supprettes No. 15A Suppositories | 30 mg powdered opium, 16.2 mg powdered belladonna extract, polyethylene glycol base | 1 or 2/day |
| B & O Supprettes No. 16A Suppositories | 60 mg powdered opium, 16.2 mg powdered belladonna extract, polyethylene glycol base | 1 or 2/day |
| Nonnarcotic Analgesic Combinations |
Components of these combinations include
Nonnarcotic analgesics: Acetaminophen, salicylates, salsalate, salicylamide.
Barbiturates, meprobamate, and antihistamines: Barbiturates, meprobamate, and antihistamines are used for their sedative effects.
Antacids: Antacids are used to minimize gastric upset from salicylates.
Caffeine: Caffeine, a traditional component of many analgesic formulations, may be beneficial in treating certain vascular headaches.
Belladonna: Belladonna alkaloids are used as antispasmodics.
Pamabrom: Pamabrom is used as a diuretic.
Cinnamedrine: Cinnamedrine, a sympathomimetic amine claimed to have a relaxant effect in the uterus, is used in products for premenstrual syndrome. Its real value has not been established.
Aminobenzoate: Aminobenzoate retards the conjugation of salicylic acid and prolongs the action of salicylates.
Other components listed but not contributing to the analgesic properties of these products include: Calcium gluconate, ipecac, and camphor.
| Nonnarcotic Analgesic Combinations | ||
| Trade Name | Strength/Ingredient | Average Dose |
| Equagesic Tablets,1 Micrainin Tablets | 325 mg aspirin, 200 mg meprobamate | 1 or 2 tablets every 2 to 6 hours |
| Magsal Tablets | 600 mg magnesium salicylate, 25 mg phenyltoloxamine citrate | 1 or 2 tablets every 2 to 6 hours |
| Phrenilin Tablets, Triaprin Capsules | 325 mg acetaminophen, 50 mg butalbital | 1 or 2 tablets or capsules every 2 to 6 hours |
| Bupap, Phrenilin Forte Capsules, Prominol, Repan, Sedapap-10 Tablets, Tencon | 650 mg acetaminophen, 50 mg butalbital | 1 or 2 tablets or capsules every 2 to 6 hours |
| Diuretic Combinations |
Fixed-dose combination drugs are not indicated for initial therapy of edema or hypertension; they require therapy titrated to the individual patient. If the fixed combination represents the determined dosage, its use may be more convenient in patient management. The treatment of hypertension and edema is not static; re-evaluate as conditions in each patient warrant.
The combination of a thiazide and a potassium-sparing diuretic provides additive diuretic activity and antihypertensive effects through different mechanisms of action and also minimizes the potassium depletion characteristic of thiazides.
Use caution when changing a patient to another triamterene/hydrochlorothiazide combination product. Combination products are not equivalent.
| Diuretic Combinations | ||
| Trade Name | Strength/Ingredient | Average Dose |
| Moduretic Tablets | 5 mg amiloride HCl, 50 mg hydrochlorothiazide | 1 to 2 tablets daily, with meals |
| Aldactazide Tablets | 25 mg spironolactone, 25 mg hydrochlorothiazide | 1 to 8 tablets daily |
| Aldactazide Tablets | 50 mg spironolactone, 50 mg hydrochlorothiazide | 1 to 4 tablets daily |
| Migraine Combinations |
Components of these combinations include
Ergotamine tartrate: Ergotamine tartrate is used for its specific action against migraine.
Caffeine: Caffeine, a cranial vasoconstrictor, is added to ergotamine to enhance vasoconstrictive effects. It may enhance the absorption of ergotamine.
Barbiturates: Barbiturates are used for sedation.
Belladonna alkaloids: Belladonna alkaloids are used for their anticholinergic and antiemetic effects in individuals experiencing excessive nausea and vomiting during attacks.
| Migraine Combinations | ||
| Trade Name | Strength/Ingredient | Average Dose |
| Cafergot Tablets, Ercaf Tablets, Wigraine Tablets | 1 mg ergotamine tartrate, 100 mg caffeine | 2 tablets at first sign of attack; follow with 1 tablet every ½ hour, if needed. Maximum dose is 6 tablets/attack. Do not exceed 10 tablets/wk. |
| Cafatine-PB Tablets | 1 mg ergotamine tartrate, 100 mg caffeine, 0.125 mg 1- alkaloids of belladonna, 30 mg sodium pentobarbital | 2 tablets at first sign of attack; follow with 1 tablet every ½ hour, if needed. Maximum dose is 6 tablets/attack. Do not exceed 10 tablets/wk. |
| Cafatine Suppository, Cafergot Suppository, Cafetrate Suppository | 2 mg ergotamine tartrate, 100 mg caffeine | Maximum dose is 2/attack. |
| Wigraine Suppository | 2 mg ergotamine tartrate, 100 mg caffeine, 21.5 mg tartaric acid | Maximum dose is 2/attack. |
Books@Ovid
Copyright © 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts